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Research finds elevated danger of neurodegenerative problems amongst COVID-19 optimistic sufferers

COVID-19 optimistic outpatients are at an elevated danger of neurodegenerative problems in contrast with people who examined adverse for the virus, a brand new examine introduced as we speak on the 8th European Academy of Neurology (EAN) Congress has proven.1

The examine, which analysed the well being data of over half of the Danish inhabitants, discovered that those that had examined optimistic for COVID-19 had been at an elevated danger of Alzheimer’s illness, Parkinson’s illness, and ischaemic stroke.

Out of the 919,731 people that examined for COVID-19 inside the examine, researchers discovered that the 43,375 individuals who examined optimistic had a 3.5 instances elevated danger of being recognized with Alzheimer’s illness, 2.6 instances with Parkinson’s illness, 2.7 instances with ischaemic stroke and a 4.8 instances elevated with intracerebral haemorrhage (bleeding within the mind). Whereas neuroinflammation might contribute to an accelerated growth of neurodegenerative problems, the authors additionally highlighted implications of the scientific deal with long-term sequelae after COVID-19.

The examine analysed in- and outpatients in Denmark between February 2020 and November 2021, in addition to influenza sufferers from the corresponding pre-pandemic interval. Researchers used statistical methods to calculate relative danger, and outcomes had been stratified for hospitalisation standing, age, intercourse, and comorbidities.

Greater than two years after the onset of the COVID-19 pandemic, the exact nature and evolution of the consequences of COVID-19 on neurological problems remained uncharacterised. Earlier research have established an affiliation with neurological syndromes, however till now it’s unknown whether or not COVID-19 additionally influences the incidence of particular neurological illnesses and whether or not it differs from different respiratory infections”.

Dr Pardis Zarifkar, Lead Writer, Division of Neurology, Rigshospitalet, Copenhagen, Denmark.

The elevated danger of most neurological illnesses was, nevertheless, no larger in COVID-19 optimistic sufferers than in individuals who had been recognized with influenza or different respiratory diseases. COVID-19 sufferers did have a 1.7 instances elevated danger of ischaemic stroke compared to influenza and bacterial pneumonia inpatients over 80 years of age.

The frequency of different neurodegenerative diseases resembling a number of sclerosis, myasthenia gravis, Guillain-Barré syndrome and narcolepsy didn’t improve after COVID-19, influenza, or pneumonia.

Dr Pardis Zarifkar added, “We discovered assist for an elevated danger of being recognized with neurodegenerative and cerebrovascular problems in COVID-19 optimistic in comparison with COVID-negative sufferers, which should be confirmed or refuted by giant registry research within the close to future. Reassuringly, aside for ischemic stroke, most neurological problems don’t seem like extra frequent after COVID-19 than after influenza or community-acquired bacterial pneumonia.”

“These findings will assist to tell our understanding of the long-term impact of COVID-19 on the physique and the position that infections play in neurodegenerative illnesses and stroke.”


  1. Frequency of neurological illnesses after COVID-19, influenza A/B and bacterial pneumonia, introduced on the EAN Congress 2022

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