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Rating the very best vitamin B12 dietary supplements of 2022

Vitamin B12 is a vital nutrient that’s troublesome to get in giant quantities in lots of meals sources, particularly in case you are a vegetarian or a vegan.

It features nearly like a hormone, and performs a job in an enormous variety of bodily features important for well being.

If you happen to aren’t positive how a lot vitamin B12 you want and the place you must get it from, we’ve bought you lined.

Our researchers dug into the scientific analysis to scout out the very best vitamin B12 dietary supplements and ranked them. On high of that, we’ve gone in-depth on the science of B12 supplementation.

Why You Ought to Belief Us

    Our advisory panel and our analysis crew rank the very best well being merchandise and dietary supplements primarily based on efficiency, label accuracy, and the efficacy of the substances within the merchandise.


Final up to date: August 31, 2022
B12 dietary supplements thought-about: 21
Hours of analysis: 43
Specialists reviewed: 9
Scientific papers referenced: 17


Greatest General

  • Some of the potent B12 dietary supplements available on the market
  • Vegan-friendly, tastes nice, and straightforward to make use of
  • 5000 mcg per serving
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Greatest for anxiousness

2. Clear Labs Vitamin B-Advanced

  • Comprises the whole vary of b-vitamins together with co-vitamins like choline, inositol and vitamin C
  • Helps keep a secure temper
  • Greatest B12 vitamin for Seniors
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Greatest for power

  • Fast under-the-tongue B12 supply mechanism
  • Has an energy-boosting properties of vitamin B12 for elevating your alertness and power ranges earlier than a exercise
  • Potent temper, mind and metabolism booster
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4. Nature Made B12 Timed Launch

  • Breaks down and transforms meals into power to maintain you going all day
  • It’s a Gluten-free with no added preservatives and no synthetic favors
  • Has a time-release system that promotes prolonged vitamin absorption within the physique
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  • It’s liquid-form that makes it uber-potent with a lightweight and candy taste to it
  • May also help with fatigue and low power to gas your physique for extra power the entire day
  • Has optimistic results on sleep and helps normalize our physique clock
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6. Backyard of Life Vitamin Code B12

  • It gives assist for digestion, metabolism, and anemia
  • Helps keep wholesome pink blood cells and wholesome nerves
  • Gives vitamins which might be from a variety of fruits, greens and its pure extracts
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7. Bronson Vitamin Sustained Launch B12

  • Sluggish launch type to supply stability stream of vitamin B12
  • Helps in power producton and in addition in mind and nervous system
  • Makes use of the best high quality of substances and is Non-GMO
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8. Zenwise Well being Vitamin B12

  • Helps to supply enegry enhance all day lengthy
  • Gives a powerful however not outrageously excessive dosage
  • Helps to steer an lively and energetic life-style at any age
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  • The epitome of a excessive dosage, fast-delivery possibility
  • Contained in fast-dissolve tablets that may quickly elevate your physique’s circulating ranges of vitamin B12
  • Straightforward to take with out water and is 100% vegetarian
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10. Jarrow Formulation Methylcobalamin

  • Provides its vitamin B12 in an artificially-sweetened chewable lozenge type
  • Maintains and helps mind and nerve well being and sleep and wake cycles
  • It’s Gluten free and free from all widespread allergens
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11. SBR Diet Vitamin B12 Drops

  • Will increase metabolism and improves digestion
  • Improves psychological readability and lifts mind fog
  • Simpler to eat
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1. Reside Acutely aware B12

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For many who’re severe about taking essentially the most potent B12 complement available on the market, Reside Acutely aware B12 doesn’t fiddle.

Reside Acutely aware B12 gives one of the vital potent B12 dietary supplements available on the market at 5000 mcg per serving. It’s designed for use sublingually and comprises essentially the most bioavailable type of B12, methylcobalamin. This ensures that extra of the B12 will get to go the place it must. It’s manufactured within the USA, underneath string GMP tips.

It’s additionally freed from soy, gluten, shellfish, dairy, and GMO’s. Reside Acutely aware goes the additional mile by offering third-party testing to make sure the purity and high quality of its B12 complement.

If you happen to’re going to take a B12 complement for power, reminiscence, and immune system operate, Reside Acutely aware B12 is your best option.

BodyNutrition‘s total #1-rated B12 winner of 2022.

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2. Twinlab B12 Dots

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TwinLabs B12 dots are nice in the event you can’t stand swallowing capsules, or if you need a fast supply of your B12 dosage.

Every 500 mcg dot quickly dissolves when positioned beneath your tongue, and the B12 is delivered proper to your bloodstream through the mucous tissue within the backside of your mouth.

Provided that these dots scored very extremely on unbiased analytical testing for purity and dosage, you possibly can make certain that you’re getting the marketed quantity of vitamin B12.

3. Nature Made B12 Timed Launch

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With 1000 mcg of vitamin B12 per serving and a specially-formulated gradual launch capsule, Nature Made delivers a simple and efficient complement.

It’s been verified for purity and dosage by unbiased laboratory testing, and it handed with flying colours. It’s very exhausting to go unsuitable with this B12 complement.

4. VeganSafe B12

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If you need a super-high dose B12 complement that’s been independently examined for purity and focus, VeganSafe B12 ought to be your selection.

It has no extraneous substances and each serving from the dropper bottle has 2500 mcg of vitamin B12.

The one draw back? it’s exhausting to persistently measure dosage from a dropper.

5. Backyard of Life Vitamin Code B12

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The vitamin B12 in Backyard of Life Vitamin Code B12 is supplied alongside extracts from a variety of vegatables and fruits.

The first disadvantage is that, as a result of B12 is usually present in dairy and animal merchandise, offering fruit and vegetable extracts could not mirror the “pure setting” during which vitamin B12 is discovered.

6. Bronson Vitamin Sustained Launch B12

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Bronson’s slow-release B12 is well-suited for long-term use due to its stable 1000 mcg dosage and its slow-release formulation.

Nonetheless, Bronson will get beat out by different dietary supplements which have unbiased lab testing of their purity.

7. MaryRuth Methyl B12 Spray

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MaryRuth Methyl B12 Spray is our go-to advice in terms of sublingual sprays. If you happen to want a fast kick of B12 for extra power, this all-natural B12 is the best way to go.

8. Natrol Vitamin B12

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Natrol’s Vitamin B12 complement is a excessive dosage, fast-delivery possibility. Its 5000 mcg of vitamin B12 will quickly elevate your physique’s circulating ranges of vitamin B12. It’s good for a fast enhance in B12, however is much less well-suited for extended use. 

9. Jarrow Formulation Methylcobalamin

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Jarrow Formulation presents its vitamin B12 in an artificially-sweetened lozenge type, which you maintain in your mouth like exhausting sweet whereas it dissolves.

The dosage may be very excessive, at 5000 mcg per lozenge, so solely use this product in case you are positive that you just want a hue dose of vitamin B12.

10. Cymbiotika B12 + B6

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Cybiotika makes a stable sublingual spray that delivers each B12 and B6, although the inclusion of B6 makes it a bit much less versatile than MaryRuth’s B12 spray.

Class winners

Greatest vitamin B12 total: Reside Acutely aware B12

Reside Acutely aware B12 has a brilliant excessive dosage and an extremely pure formulation. The liquid formulation makes it simple to include into protein shakes and inexperienced drinks, and the citrus taste makes it simple to take by itself, too. Simply the very best all-around B12 complement available on the market.

Greatest vitamin B12 for power: Twinlab B12 Dots

If you happen to want power quick, Twinlab B12 Dots are the best way to go. One dot held underneath your tongue delivers a fast surge of B12 to your bloodstream, serving to to quickly heighten your power ranges.

Greatest vitamin B12 for vegans: Reside Acutely aware B12

Reside Acutely aware B12 is a liquid-based B12 complement that’s vegan-friendly, tastes nice, and straightforward to make use of, making it the clear winner for vegans wanting to make sure their B12 ranges keep within the optimum vary. 

Greatest vitamin B12 for anxiousness: Nature Made B12 Timed Launch

Deficiencies in B12 and different B-complex nutritional vitamins are identified to be related to anxiousness, melancholy, and different temper disturbances. Nature Made’s time launch complement is a superb possibility for sustaining a secure temper all through the day. 

Greatest vitamin B12 for seniors: Nature Made B12 Timed Launch

Seniors are sometimes poor in vitamin B12, and supplementing with a formulation that offers you a long-lasting enhance to your B12 ranges is an effective way to maintain larger B12 all day. That’s why we suggest the time launch formulation from Nature Made. 

Greatest vitamin B12 for exercise efficiency: Twinlab B12 Dots

The energy-boosting properties of vitamin B12 make it an excellent possibility for elevating your alertness and power ranges earlier than a exercise. Our favourite complement for this function is Twinlab B12 Dots, due to its fast under-the-tongue B12 supply mechanism.

Who can buy vitamin B12?

Vitamin B12 might be difficult to get in your weight loss plan, particularly in case you have any dietary restrictions: it’s present in respectable quantities in only a few meals, which embody beef, eggs, rooster, and dairy. The relative rarity of B12 means the next teams of persons are particularly well-suited for a B12 complement:

Vegans and vegetarians. Because the richest sources of pure B12 are all in animal merchandise, a B12 complement is a downright necessity for vegetarians and vegans.

Certainly, analysis persistently demonstrates that vegans and vegetarians who don’t complement with B12 are sometimes poor (1, 2).

Pregnant and nursing girls. B12 is a standard ingredient in prenatal nutritional vitamins due to the advantages of sufficient B12 consumption in your child.

Younger kids. Most of the identical advantages of B12 for infants carry over to younger kids: B12 can be a key ingredient in any high-quality multivitamin for teenagers as a result of its significance for cognitive growth. 

Older adults. B12 has been the main focus of analysis into stopping or slowing cognitive decline in older adults, and B12 deficiency is sort of widespread amongst older adults, presumably as a result of decreased bioavailability of B12 as you become older. For seniors, a B12 complement is an efficient addition to your supplementation routine. 

Individuals who have had weight reduction surgical procedure. Bariatric surgical procedure can hamper your potential to soak up micronutrients out of your weight loss plan, particularly B12. A complement is a superb thought for individuals who’ve had surgical procedure to reduce weight.

How we ranked

Given the dietary significance of vitamin B12, our rankings have been strongly knowledgeable by the dosages and complement types utilized by scientific trials and scientific experiments on vitamin B12.

We used the next evidence-based tips to tell our rankings: 

Efficient B12 dosageSince analysis has discovered that complement dosages of not less than 500 to 1000 mcg of B12 are optimum for restoring B12 ranges again to regular, we eradicated dietary supplements that had a decrease dosage than this from consideration.

Deal with B12, not simply B-vitamins usually. B12 has some distinctive properties that set it aside from the opposite B nutritional vitamins, so we didn’t rank merchandise that didn’t put B12 on the heart of their formulation, like 365 B-Advanced or Thorne Analysis Primary B Advanced.

Environment friendly supply mechanismCapsule primarily based dietary supplements had a transparent benefit, as a result of their potential to ship a exact dosage each time.

Nonetheless, not everybody is ready to swallow capsules—particularly older adults, who’re disproportionately represented amongst individuals who have low ranges of B12.

So, we additionally analyzed the 2 competing types of supply for B12: gummies and liquid dietary supplements.

Liquid dietary supplements might be useful in the event you already make a protein shake or inexperienced drink, however they’ve the drawback of not being significantly simple to get a dependable dosage.

All-natural substances and no fillers. No gummy merchandise made the lower, since even the very best choices have been too bloated with synthetic flavors, colours, and binders. 

Clear complement designWe utilized the identical strict requirements of purity and clear complement design to the liquid and capsule primarily based dietary supplements as properly, rewarding merchandise that stored pointless substances to a minimal.

After sorting the remaining merchandise in line with high quality, we had our last rankings: the very best B12 dietary supplements which might be accessible available on the market.


Vitamin B12 is critical for an enormous variety of bodily features and may solely be present in animal sources. Tlisted here are no plant-based sources of vitamin B12, apart from meals which might be fortified with added B12 (3).

Decrease ranges of vitamin B12 may cause anemia and fatigue, so it’s essential to maintain excessive ranges of this vitamin.

B12 can provide you extra power. B12 can be usually used as an power complement, which is why it’s included in many alternative power drinks (4).

An absence of vitamin B12 may cause weak spot, dizziness, pale pores and skin, and constipation. These issues are widespread amongst folks in teams with B12 deficiency, like older adults, vegetarians, and vegans (5). 

Vitamin B12 deficiency is a number one explanation for anemia. An absence of vitamin B12 can restrict your ranges of pink blood cells which provide oxygen to your muscle mass. It will manifest as weak spot, fatigue, and poor efficiency throughout train (6).

The prevalence of vitamin B12 deficiency may be very excessive. Shut to 6 % of older adults are B12 clinically poor, and a further 20% of individuals have “marginal” B12 ranges, which means they’re proper on the sting of low vitamin B12 (7).

B12 dietary supplements can repair B12 deficiency, however it might take as much as six months. That’s in line with analysis printed within the New England Journal of Drugs, which adopted folks with B12 deficiency after they began taking a B12 complement (8).

Low ranges of vitamin B12 could also be implicated within the growth of cognitive decline. One research recognized low B12 as a big threat issue for Alzheimer’s illness and dementia (9).

The researchers discovered that low ranges of vitamin B12 elevated Alzheimer’s illness by 4.5-fold.

B12 deficiency is related to melancholy. When in comparison with wholesome topics, folks with melancholy usually tend to have decrease B12 ranges, in line with a research in Rotterdam (10).

Cardiovascular well being is carefully related to vitamin B12. A research printed in Circulation confirmed that larger blood ranges of vitamin B12 was protecting in opposition to heart problems (11).

Vitamin B12 is important for kids and girls who’re pregnant. Whereas folate will get plenty of the eye throughout being pregnant, B12 issues too.

A working group from the World Well being Group experiences that deficiencies in B12 throughout being pregnant enhance the danger of neural tube defects, a severe delivery defect (12).

Some analysis additionally helps an affiliation between low maternal ranges of B12 and different delivery defects too, however the proof shouldn’t be as robust.

The significance of B12 for well being doesn’t finish after delivery. Kids who’re poor in vitamin B12 undergo developmental delays, and should not ever absolutely restoration.

Amongst schoolchildren, the working group famous that decrease ranges of B12 correlated with worse grades and decrease scores on exams of cognitive potential.

Weight reduction surgical procedure may cause vitamin B12 deficiency. Getting bariatric surgical procedure, like a lap band or gastric bypass, generally is a life-changing process for people who find themselves very overweight. 

Nonetheless, one of many surprising unintended effects of those procedures might be B12 deficiency, which might be handled with supplementation (13).

Unwanted effects

Whereas short-term use of vitamin B12 has no quick unintended effects, even at very excessive doses, taking excessive doses over an extended time period does appear to be linked to an elevated threat of lung most cancers, however solely in males.

Lengthy-term B12 use in people who smoke would possibly enhance lung most cancers threat. A research from the Ohio State College discovered that males taking excessive doses of vitamin B12 had two to 4 instances the incidence of lung most cancers in comparison with males who didn’t take excessive doses of B12 (14).

This threat must be weighed in opposition to the advantages of B12 supplementation and the dangers of B12 deficiency.

Advisable dosage

B12 supplementation has fairly agency suggestions on dosage for restoring correct B12 ranges.

Goal for 500 to 1000 mcg per day to deal with B12 deficiency. This quantity comes from a research that examined doses of two.5 to 1000 micrograms per day of vitamin B12 over the course of a number of weeks to see which doses elicited essentially the most fast restoration of B12 ranges (15).

Later, you possibly can decrease your consumption to take care of your ranges (for instance, throughout being pregnant you want a a lot smaller minimal of 2-2.5 mcg per day (16) in case you are not already poor).


Q: What meals are excessive in vitamin B12? 

A: The record of meals which might be excessive in B12 is surprisingly brief. Beef, salmon and different fish, milk, cheese and different dairy merchandise, and eggs kind of spherical out the numerous sources of pure B12.

Whereas different meals like breakfast cereals are sometimes listed as being excessive in vitamin B12, these meals are fortified with supplemental vitamin B12.

Q: Is it okay to take B12 as a vitamin complement? 

A: Sure, vitamin B12 is extraordinarily protected. No important hostile results have been related to acute consumption of vitamin B12, in line with the Nationwide Institute of Well being’s Workplace of Dietary Dietary supplements (17).

As famous within the unintended effects part of this text, one research discovered an affiliation between long-term use of vitamin B12 and an elevated threat of lung most cancers, although extra analysis is required to copy this discovering.

Individuals who smoke or who’re in any other case at excessive threat for lung most cancers could need to discuss to their physician earlier than taking a vitamin B12 complement long-term, however apart from this, it’s okay to take a B12 complement.

Q: What’s cobalamin? 

A: Cobalamin is one other title for vitamin B12. The phrases are interchangeable, so vitamin B12 means the identical factor as cobalamin. The precise title comes from the truth that the vitamin B12 molecule has an ion of cobalt at its core.

There’s a little bit of confusion concerning B12 and lots of the different B nutritional vitamins, as they usually have different names (folate, for instance, is identical factor as vitamin B9), however so long as you recognize that they’re one and the identical, it shouldn’t trigger you any bother.

Q: What does B12 do throughout being pregnant? 

A: Even in adults, vitamin B12 is thought to be crucial for correct functioning of the central nervous system. When you recognize this, it shouldn’t be shocking that B12 performs an vital function within the growth of your child’s central nervous system and mind.

Neural tube defects, or NTDs, the delivery defect that’s most strongly related to vitamin B12 deficiency, is a defect of the central nervous system.

Q: Are you able to overdose on vitamin B12?

A: No. B12 is without doubt one of the most secure vitamin dietary supplements you possibly can take. B12 is a water-soluble vitamin, so any extra is solely eradicated in urine.

There have been no documented instances of overdose on vitamin B12, and certainly, you’ll discover many examples of dietary supplements that present huge doses of vitamin B12 with no obvious ailing impact. 

Q: Is getting a B12 injection higher than taking a complement? 

A: Vitamin B12 injections have been developed for individuals who have poor pure absorption of vitamin B12 from meals and dietary supplements, or who may not reliably have the ability to take a B12 complement.

Sure genetic circumstances can considerably restrict your physique’s potential to soak up vitamin B12, so folks with these circumstances usually get a B12 injection as a substitute of taking a complement.

Likewise, some individuals who have gastric bypass surgical procedure or one other bariatric (weight reduction) surgical process could elect to get an occasional B12 injection as a substitute of taking a complement.

On stability, although, most individuals are higher off with a complement if they’re able to taking them: dietary supplements are cheaper and far simpler to get.

Q: Are you able to get B12 from greens? 

A: No, there are not any plant-based sources of B12, which is why vegans are at a excessive threat for vitamin B12 deficiency. The one naturally occurring sources of B12 are literally micro organism, that are consumed after which dwell as a part of the probiotic flora inside ruminants like cows.

These micro organism proceed producing B12, which step by step accumulates in animal tissue. That’s why the one sources of it are animal-derived meals like dairy, eggs, and meat.

In case you are a vegan, vegetarian, or just don’t eat a lot in the best way of meat, a B12 complement is a particularly good funding on your well being. 

Q: What are the signs of B12 deficiency? 

A: Vitamin B12 deficiency can manifest as tingling, pins and needles sensations, fatigue, continuous tiredness, and pale pores and skin.

Not the entire signs are simply observable bodily signs, although. B12 deficiency can even manifest as temper adjustments, melancholy, forgetfulness, and different reminiscence issues.

You could really feel as if you’re in a continuing “psychological fog” for no obvious motive. When you’ve got these signs, it’s value getting your vitamin B12 ranges checked.

It’s significantly vital to take action in case your weight loss plan is fairly wholesome—there could also be an underlying medical trigger for B12 deficiency, like celiac illness and different gastrointestinal problems. 

Q: Are you able to get vitamin B12 naturally? 

A: Sure, however solely from animal meals. The one pure supply of vitamin B12 is from meals like beef, eggs, dairy, and fish.

Whereas crops are nice sources of many different nutritional vitamins and minerals, you gained’t have the ability to get even hint quantities of pure vitamin B12 from any plant primarily based meals.

Some meals—significantly breads, breakfast cereals, and rice—are sometimes fortified with vitamin B12, so these meals could make appearances on lists of high sources of vitamin B12, however these will not be naturally occurring sources of B12.

Associated articles


Vitamin B12 is a crucial nutrient that performs a protecting and preventative function in a number of continual ailments, together with Alzheimer’s illness and melancholy.

Vitamin B12 deficiency is quite common; as much as 1 / 4 of older adults have or are at excessive threat for B12 deficiency. A deficiency in vitamin B12 might be mounted with a number of weeks of supplementation at 500 to 1000 micrograms per day, and a decrease dose later to take care of sufficient ranges of B12 within the physique.

Males, particularly males who smoke, ought to be hesitant to take excessive doses of B12 for lengthy durations, however the dangers of B12 deficiency have to be thought-about as properly.

For BodyNutrition’s #1 vitamin B12 advice, click on right here.

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